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Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.〔 A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.〔Grant RL, Combs AB, Acosta D (2010). "Experimental Models for the Investigatio of Toxicological Mechanisms". In McQueen CA. ''Comprehensive Toxicology'' (2nd ed.). Oxford: Elsevier. p. 204. ISBN 978-0-08-046884-6.〕 Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there. Drugs that do not bind to receptors produce their corresponding therapeutic effect by simply interacting with chemical or physical properties in the body. Common examples of drugs that work in this way are antacids and laxatives.
In comparison, a mode of action (MoA) describes functional or anatomical changes, at the cellular level, resulting from the exposure of a living organism to a substance.
== Drugs with known mechanisms of actions ==
There are many drugs in which the mechanism of action is known. By knowing the interaction between a certain sight of a drug and a receptor, other drugs can be formulated in a way that replicates this interaction, thus producing the same therapeutic effects. Indeed, this method is used to create new drugs.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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